Succinimidyl 6-(3-[2-pyridyldithio]-propionamido)hexanoate (LC-SPDP) is a cleavable, water insoluble, amino and thiol (sulfhydryl) reactive heterobifunctional crosslinking reagent. The "long chain" LC-SPDP crosslinking reagent has a 15.7 angstrom spacer arm, compared to the shorter 6.8 angstrom spacer arm version of SPDP crosslinker. Often, due to steric hindrances, it is desirable to empirically test which of the two versions will work best in your specific application.
LC-SPDP crosslinking reagent's reactive moites consist of an N-hydroxysuccinimide (NHS) ester that reacts with primary amines, as found in lysine side chains. While on the other end of the LC-SPDP crosslinking reagent pyridinyldisulfide reacts with sulhydryls to yield a reversible disulfide bond.
Molecular Weight: 425.5
Spacer Length: 15.7 Å
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