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Sodium meta-Periodate 5 grams


Sodium meta-Periodate (NaIO4) is a useful reagent for the oxidation of carbohydrates to aldehydes. Sodium meta-Periodate converts hydroxyls (-OH) to aldehydes that then react with hydrizide groups. Sodium m-Periodate reacts most efficiently with cis-diols (as found in Sialic Acid) at a concentration of 1mM, but increasing concentrations (>10mM) should ensure oxidation of many sugar residues.

Carbohydrate moites on glycoproteins can be conveniently oxidized to aldehydes in a 10mM periodate solution for 30 minutes and then desatled. The resulting aldehydes can be conjugated to hydrizide groups of PDPH crosslinker or Biotin-Hydrizide for protein crosslinking or biotinylation of your glycoprotein, respectively.

Molecular Weight: 213.89

CAS Number: 7790-28-5

Alternative Name: Sodium Periodate; Periodic Acid (HIO4), Sodium Salt; NaIO4

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