BS3 crosslinker (Bis[sulfosuccinimidyl] suberate; Sulfo-DSS; BSSS) is an amine-reactive, water soluble, homobifunctional protein crosslinker. Due to BS3 crosslinking reagent's water solubility, conjugation reactions conveniently can take place at physiological conditions. The 8-atom spacer arm of the BS3 crosslinking reagent is non-cleavable and the molecule is not cell membrane permeable. The BS3 protein crosslinker possesses amino reactive Sulfo-NHS esters on both ends of the molecule and can be used to prepare antibody-protein conjugates, for crosslinking cell surface proteins, and for covalently orienting antibody to an immobilized Protein A or Protein G resin.

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Molecular Weight: 572.43

Spacer Length: 11.4 Å

CAS Number: 82436-77-9

Alternative Names: Bis(sulfosuccinimidyl) suberate; Suberic acid bis(3-sulfo-N-hydroxysuccinimide ester); Bis(sulfosuccinimidyl)suberate; BS³; Sulfo-DSS; BS 3; BSSS

References:
Ferns, J. E., Theisen, C. S., Fibuch, E. E., & Seidler, N. W. (2012). Protection against protein aggregation by alpha-crystallin as a mechanism of preconditioning. Neurochemical research, 37(2), 244-252.

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