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Succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate (SMCC) is a heterobifunctional crosslinker with a maleimide group that is sulfhydryl (thiol; -SH) reactive and a NHS ester that is amine reactive. SMCC crosslinking reagent must be dissolved in an organic solvent, such as DMSO or DMF, and then can be added to an aqueous crosslinking reaction. SMCC crosslinking reagent is permeable across the lipid bilayer of the cell membrane and can be used to crosslink intracellular proteins and peptides. SMCC crosslinking reagent is permeable across the lipid bilayer of the cell membrane. The 9 atom spacer arm of SMCC is not cleavable.
Click here for: SMCC Product Information Sheet & General Protocol
Molecular Weight: 334.32
Spacer Length: 8.3 Å
CAS Number: 64987-85-5
Alternative Names: 4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester; N-Succinimidyl 4-(maleimidomethyl)cyclohexanecarboxylate; Succinimidyl trans-4-(N-maleimidylmethyl)cyclohexane-1-carboxylate
Special bulk pricing is available on bulk quantities of SMCC for your large volume manufacturing application.