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![Sulfosuccinimidyl 6-(3'-[2-pyridyldithio]-propionamido)hexanoate, Sulfo-LC-SPDP crosslinker structure, CAS # n/a](http://proteochem.com/images/structure_images/SULFO-LC-SPDP-crosslinker-structure.gif)
Sulfo-LC-SPDP protein crosslinking reagent, Sulfosuccinimidyl 6-(3'-[2-pyridyldithio]-propionamido)hexanoate, is one of three SPDP variants produced by ProteoChem (LC-SPDP is the other). Sulfo-LC-SPDP is a cleavable, water soluble, amino and thiol (sulfhydryl) reactive heterobifunctional protein crosslinker. The "long chain" Sulfo-LC-SPDP crosslinking reagent has a 15.7 angstrom spacer arm, and is the water soluble analog of LC-SPDP crosslinker.
Sulfo-LC-SPDP crosslinker's reactive groups include N-hydroxysulfosuccinimide (Sulfo-NHS) ester that reacts with primary amines, as found in lysine side chains; while on the other end of the Sulfo-LC-SPDP crosslinking molecule pyridinyldisulfide reacts with sulhydryls to yield a reversible disulfide bond. The disulfide bond can be reduced with TCEP-HCl or DTT to reverse the crosslinked proteins.
Click here for: Sulfo-LC-SPDP Crosslinker Protocol & Product Information Sheet
Molecular Weight: 527.57
Spacer Length: 15.7 Å
References:
Méndez, J., Monteagudo, A., & Griebenow, K. (2012). Stimulus-responsive controlled release system by covalent immobilization of an enzyme into mesoporous silica nanoparticles. Bioconjugate chemistry, 23(4), 698-704.
Ciani, I., Schulze, H., Corrigan, D. K., Henihan, G., Giraud, G., Terry, J. G., ... & Mount, A. R. (2012). Development of immunosensors for direct detection of three wound infection biomarkers at point of care using electrochemical impedance spectroscopy. Biosensors and Bioelectronics, 31(1), 413-418.
Special bulk pricing is available on bulk quantities of Sulfo-LC-SPDP crosslinker for your large volume manufacturing application.
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