SATA protein modifier (N-Succinimidyl S-Acetylthioacetate) is a protein modification reagent used to convert primary amine groups into protected sulfhydryls (thiol; -SH) for later reaction with sulfhydryl reactive crosslinkers such as Sulfo-SMCC, Sulfo-MBS, etc. The sulfhydryl is readily made available for use in subsequent reactions after exposure to Hydroxylamine. After the simple deprotection step is performed to create the thioacetylated peptide, the free sulfhydryl containing peptide can then be conjugated to make a hapten-carrier conjugate, polymer, etc.

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