DCC crosslinker (N,N'-dicyclohexylcarbodiimide) is a zero-length crosslinker that is often employed in peptide synthesis and organic synthesis. DCC's carbodiimide is useful for coupling amines and carboxylates without the insertion of spacer atoms. DCC crosslinker is commonly used in the synthesis of active ester-containing reagents.

DCC is soluble in a wide range of solvents including: DMSO, DMF, Dichloromethane, Ethyl Acetate, etc. The urea by-product is conveniently insoluble in these solvents, making its removal simple by filtration.